Description

2-Pyrrolidine-2,3,4,5-13C4-1-15N-Carbonitrile-13C, 1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]Dec-1-Yl)Amino]Acetyl]-, (2S)- is a high-purity, multi-labeled stable isotope compound, specifically designed for advanced research and development applications. Its core value lies in providing a critical, isotopically enriched building block for metabolic pathway tracing, pharmacokinetic studies, and the synthesis of labeled active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise analytical tools for drug discovery and development.

Application

• Isotopic Tracer in Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a labeled precursor to synthesize isotopically labeled drug candidates for mass spectrometry-based analysis of absorption, distribution, metabolism, and excretion (ADME).
• Internal Standard for Quantitative Bioanalysis: Serves as a high-quality internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods to ensure accurate quantification of target analytes in complex biological matrices.
• Synthesis of Labeled Active Pharmaceutical Ingredients (APIs): A key intermediate in the multi-step synthesis of 13C and 15N-labeled pharmaceutical compounds for clinical research and regulatory submission packages.
• Proteomics and Metabolomics Research: Employed in the development of labeled probes and standards for advanced mass spectrometry workflows aimed at understanding protein interactions and metabolic networks.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: The specific isotopic labeling pattern facilitates detailed structural and dynamic studies of molecules and their interactions in solution.

Basic Information

Product Name	2-Pyrrolidine-2,3,4,5-13C4-1-15N-Carbonitrile-13C, 1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]Dec-1-Yl)Amino]Acetyl]-, (2S)-
CAS No.	1044741-01-6
Molecular Formula	C1713C4H2515N2O2 *
Molecular Weight	~309.4 g/mol (for labeled form) *
Synonyms	(2S)-1-[2-[(3-Hydroxyadamantan-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile-2,3,4,5-13C4-1-15N-13C
13C4,15N-Labeled P5C-110
Labeled Adamantylglycyl-pyrrolidine-2-carbonitrile
Stable Isotope Labeled DPP-4 Inhibitor Intermediate
Multi-labeled Saxagliptin Related Compound
[13C4,15N]-1-((2S)-2-Cyanopyrrolidin-1-yl)-2-(3-hydroxyadamantan-1-ylamino)acetyl-13C
Isotopic Labeled Pyrrolidine Carbonitrile Derivative
EINECS	Contact for details

* The exact molecular weight depends on the isotopic enrichment levels. Contact us for precise calculation based on your specification.

Quality Control

This high-value stable isotope compound is produced and controlled under a strict quality management system. Certificates of Analysis (COA) are provided with each batch, detailing critical parameters including isotopic purity (Atom % 13C and 15N), chemical purity (by HPLC), and specific identity confirmation. Our quality protocols are designed to meet the exacting standards required for pharmaceutical research and regulatory submission.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C *
Isotopic Purity (15N)	≥ 98 atom % 15N *
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.

* Standard enrichment levels are listed. Custom isotopic enrichment is available upon request.