Description

10-Oxo Buprenorphine is a key pharmaceutical intermediate and reference standard of significant importance in analytical and research chemistry. This compound is critical for quality control and method development in the synthesis and analysis of buprenorphine-related substances. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions involved in opioid antagonist development, forensic analysis, and metabolite studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of buprenorphine and its analogs.
• Analytical Reference Standard: Used for the identification, quantification, and purity assessment of buprenorphine and related compounds in HPLC, LC-MS, and GC-MS methods.
• Metabolite Studies: Serves as a reference material for the study of buprenorphine metabolism and pharmacokinetics.
• Forensic Analysis: Employed as a certified standard in forensic toxicology for the accurate detection of substances in biological samples.
• Quality Control (QC): Essential for pharmaceutical QC laboratories to verify the identity and purity of active pharmaceutical ingredients (APIs) and finished products.
• Research & Development: Used in preclinical and clinical research to develop new therapeutic agents and diagnostic assays.

Basic Information

Product Name	10-Oxo Buprenorphine
CAS No.	1044710-08-8
Molecular Formula	C29H41NO5
Molecular Weight	483.64 g/mol
Synonyms	10-Oxobuprenorphine; 21-Cyclopropyl-7α-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine-10-one; Buprenorphine Impurity F (10-Oxo); Buprenorphine Related Compound F; 10-Ketobuprenorphine; Buprenorphine-10-one
EINECS	Contact for details

Quality Control

Our 10-Oxo Buprenorphine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets high-purity standards suitable for pharmaceutical research and analytical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.