Description

2,4,5-Trifluoro-Dl-Phenylglycine is a fluorinated amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and high-value building block for constructing complex molecules, particularly in the pharmaceutical sector. It is primarily needed by research institutions and manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where fluorine substitution enhances efficacy and environmental persistence.
• Peptide Modification: Incorporated into synthetic peptides to study structure-activity relationships (SAR) and improve peptide stability against enzymatic degradation.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create labeled analogs for metabolic pathway studies and biochemical assays.

Basic Information

Product Name	2,4,5-Trifluoro-Dl-Phenylglycine
CAS No.	1043500-64-6
Molecular Formula	C8H6F3NO2
Molecular Weight	209.13 g/mol
Synonyms	DL-2,4,5-Trifluorophenylglycine; (RS)-2-Amino-2-(2,4,5-trifluorophenyl)acetic acid; 2,4,5-Trifluoro-α-aminophenylacetic acid; 2-Amino-2-(2,4,5-trifluorophenyl)ethanoic acid; (±)-2,4,5-Trifluorophenylglycine; 2,4,5-Trifluoro-DL-α-phenylglycine; (Rac)-2,4,5-Trifluorophenylglycine
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluoro-Dl-Phenylglycine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-Racemate
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.