Description

2,6-Difluoro-3-Methyl-Dl-Phenylalanine is a fluorinated, non-natural amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a versatile chiral building block, enabling the precise introduction of fluorine atoms and methyl-substituted phenylalanine motifs into complex molecular architectures. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and agrochemical intermediates where structural modification is critical for activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetics & PROTACs: Used to construct modified peptide backbones and linkers in proteolysis-targeting chimeras (PROTACs) to enhance binding affinity and pharmacokinetic properties.
• Agrochemical Synthesis: Acts as a precursor in the synthesis of advanced herbicides and pesticides, leveraging the fluorine atoms to improve lipophilicity and biological activity.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal chemistry.
• Ligand & Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Bioconjugation & Probe Synthesis: Useful for creating fluorescent or affinity probes for biochemical and diagnostic applications.

Basic Information

Item	Details
Product Name	2,6-Difluoro-3-Methyl-Dl-Phenylalanine
CAS No.	1043500-56-6
Molecular Formula	C10H11F2NO2
Molecular Weight	215.20 g/mol
Synonyms	DL-2,6-Difluoro-3-methylphenylalanine; 3-Methyl-2,6-difluorophenylalanine, DL-; (RS)-2-Amino-3-(2,6-difluoro-3-methylphenyl)propanoic acid; 2,6-Difluoro-3-methyl-DL-phenylalanine; 2,6-Difluoro-3-methyl-α-aminohydrocinnamic acid; (DL)-2,6-Difluoro-3-methylphenylalanine; α-Amino-2,6-difluoro-3-methylbenzenepropanoic acid
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-3-Methyl-Dl-Phenylalanine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for advanced research and development. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.