Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl Tyr(2,6-Me2,4-Tbu)-Oh is a specialized, protected tyrosine derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity, structurally complex amino acid analogs for the development of novel peptides and bioconjugates. It is primarily utilized in pharmaceutical R&D, particularly in solid-phase peptide synthesis (SPPS) for creating therapeutic peptides and exploring structure-activity relationships.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected, side-chain modified tyrosine residue for the controlled assembly of complex peptide sequences.
• Pharmaceutical Research & Development: Used as an intermediate in the discovery and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation and Probe Development: The unique dimethyl and tert-butyl substituted aromatic ring makes it valuable for creating labeled peptides or modifying peptide physicochemical properties.
• Chemical Biology Studies: Employed to incorporate non-natural, sterically hindered tyrosine analogs into proteins or peptides to study protein function, stability, and interactions.
• Process Development for API Manufacturing: Acts as a crucial raw material in the scalable synthesis of Active Pharmaceutical Ingredients (APIs) containing modified tyrosine.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl Tyr(2,6-Me2,4-Tbu)-Oh
CAS No.	1043043-79-3
Molecular Formula	C31H35NO5
Molecular Weight	501.62 g/mol
Synonyms	Fmoc-Tyr(2,6-diMe-4-tBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2,6-dimethyl-4-tert-butylphenyl)-L-tyrosine; Fmoc-L-Tyr(2,6-Me2,4-tBu)-OH; Fmoc-3-(2,6-dimethyl-4-tert-butylphenoxy)-L-phenylalanine; Fmoc-Tyr(DiMe-tBu)-OH; Protected Tyrosine Derivative; Amino Acid Building Block Fmoc-Tyr(X)-OH
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl Tyr(2,6-Me2,4-Tbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for advanced pharmaceutical intermediates, ensuring reliable supply and traceability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.