Description

2,2-Difluoro-2-(3-Fluorophenyl)Acetic Acid is a high-value fluorinated aromatic building block, essential for introducing difluoroacetic acid motifs into complex molecular architectures. Its unique structure, featuring two fluorine atoms on the alpha carbon, makes it a critical intermediate for synthesizing advanced pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of modern herbicides, fungicides, and insecticides where the difluoroacetate group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic electronic materials to modify solubility and electronic properties.
• Chemical Biology Probes: Utilized in the design of enzyme inhibitors and molecular probes for biochemical and pharmacological research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2,2-Difluoro-2-(3-Fluorophenyl)Acetic Acid
CAS No.	1042623-00-6
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	3-Fluoro-α,α-difluorobenzeneacetic Acid; (3-Fluorophenyl)difluoroacetic Acid; 2,2-Difluoro-2-(3-fluorophenyl)ethanoic Acid; α,α-Difluoro-3-fluorophenylacetic Acid; 3-Fluorobenzeneacetic Acid, α,α-difluoro-; 1042623-00-6; DFFA
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-2-(3-Fluorophenyl)Acetic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.