Description

[4-[4-[3-Oxo-6′-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Isobenzofuran-1(3H),9′-[9H]Xanthen]-3′-Yl]-1-Piperazinyl]Butyl]Triphenyl-Phosphonium Iodide is a sophisticated multifunctional organic salt that combines a fluorescent xanthene core with a boronate ester and a triphenylphosphonium cation. This compound is engineered for targeted delivery and sensing applications, leveraging its unique structural components. It is primarily utilized by researchers and developers in the fields of chemical biology, medicinal chemistry, and advanced materials science for creating probes, conjugates, and targeted delivery systems.

Application

• Mitochondria-Targeted Fluorescent Probes: The triphenylphosphonium moiety facilitates accumulation in mitochondria, making this compound a key precursor for developing organelle-specific bioimaging agents.
• Reactive Oxygen Species (ROS) Sensing: The fluorophore core can be utilized in the design of turn-on or ratiometric fluorescent sensors for detecting cellular oxidative stress.
• Bioconjugation and Prodrug Synthesis: The boronate ester group serves as a versatile handle for bioorthogonal chemistry, enabling conjugation to biomolecules or the construction of stimulus-responsive prodrugs.
• Polymer and Materials Functionalization: Used as a monomer or functional additive to incorporate fluorescent and targeting properties into polymers, nanoparticles, and other advanced materials.
• Chemical Biology Research: Serves as a critical intermediate in synthesizing tool compounds for studying cellular processes, protein interactions, and signaling pathways.
• Pharmaceutical Development: Investigated for its potential in creating targeted therapeutic agents that combine diagnostic (theranostic) and treatment functions.

Basic Information

Product Name	[4-[4-[3-Oxo-6′-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Isobenzofuran-1(3H),9′-[9H]Xanthen]-3′-Yl]-1-Piperazinyl]Butyl]Triphenyl-Phosphonium Iodide
CAS No.	1041634-69-8
Molecular Formula	C55H59BN2O5P·I
Molecular Weight	~1009.77 g/mol (Iodide salt)
Synonyms	TPP-Ros-BPin; Triphenylphosphonium-Rosamine-Boronate; Mitochondria-targeted ROS probe precursor; 6'-BPin-TPP-Rosamine Iodide; (6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3',6'-bis(diethylamino)spiro[isoindoline-1,9'-xanthen]-3-one) Triphenylphosphonium Salt; Boronic ester functionalized xanthene-phosphonium salt; Fluorescent phosphonium boronate
EINECS	Contact for details

Quality Control

We supply this high-value research chemical with a commitment to exceptional purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR (1H, 13C, 31P, 11B) for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. Our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	Red to purple solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.