Description

Oxazole,2-[(1S)-7'-[Bis[3,5-Bis(1,1-Dimethylethyl)Phenyl]Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Inden]-7-Yl]-4,5-Dihydro- is a sophisticated chiral phosphine-oxazole hybrid ligand, representing a high-value specialty chemical for advanced catalytic processes. Its core value lies in enabling highly selective and efficient asymmetric synthesis, which is critical for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty materials sectors who require precise stereocontrol in metal-catalyzed reactions such as hydrogenations and cross-couplings.

Application

• Asymmetric Catalysis: As a key chiral ligand for transition metal catalysts (e.g., Rh, Ru, Ir) in enantioselective hydrogenation and other C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and oncology.
• Agrochemical Research: Used in the development of chiral pesticides and herbicides where specific stereochemistry is required for biological activity and environmental safety.
• Fine Chemical Manufacturing: Facilitating the synthesis of complex, high-value flavor and fragrance compounds, as well as advanced material precursors.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.
• Process Chemistry Optimization: Implementation in scale-up and pilot plant studies to improve the yield, selectivity, and cost-efficiency of commercial synthetic routes.

Basic Information

Item	Details
Product Name	Oxazole,2-[(1S)-7'-[Bis[3,5-Bis(1,1-Dimethylethyl)Phenyl]Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Inden]-7-Yl]-4,5-Dihydro-
CAS No.	1040274-18-7
Molecular Formula	C55H66NOP
Molecular Weight	788.09 g/mol
Synonyms	(S)-2-(7'-(Bis(3,5-di-tert-butylphenyl)phosphino)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7-yl)-4,5-dihydrooxazole; (S)-SpiroBI-Dihydrooxazole Phosphine Ligand; (S)-SPO Ligand; Chiral Spiro Phosphinooxazoline; (S)-2-[7'-[Bis(3,5-di-tert-butylphenyl)phosphino]-2,2',3,3'-tetrahydrospiro[1H-indene-1,1'-inden]-7-yl]-4,5-dihydro-1,3-oxazole; Ligand 1040274-18-7; (S)-Indane-Spiro Phosphinooxazoline
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet the exacting standards required for catalytic applications. We employ advanced techniques including HPLC, NMR (¹H, ³¹P, ¹³C), and chiral analysis to guarantee batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality management system supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and catalytic performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.