Description

(Sa,S)-Dtb-Ph-Siphox is a high-purity, chiral phosphine-oxazoline (PHOX) ligand, a critical class of organocatalysts in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, which are essential for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This product is specifically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation and cross-coupling reactions.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for prochiral olefins, ketones, and imines.
• As a catalyst component in enantioselective cross-coupling reactions (e.g., Suzuki-Miyaura, Heck).
• For the development of stereoselective synthetic routes to pharmaceutical intermediates and active ingredients.
• In academic and industrial R&D for exploring new catalytic methodologies.
• For the synthesis of chiral natural products and complex molecules.
• In process chemistry for the scale-up of enantiopure compounds.

Basic Information

Product Name	(Sa,S)-Dtb-Ph-Siphox
CAS No.	1040274-12-1
Molecular Formula	C24H31NO2PSi
Molecular Weight	424.57 g/mol
Synonyms	(Sa,S)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-(1,1-dimethylethyl)-2-oxazole; (Sa,S)-2-[2-(Diphenylphosphino)phenyl]-4-(tert-butyl)-4,5-dihydrooxazole; (Sa,S)-t-Bu-PHOX; (Sa,S)-DTB-PHOX; (Sa,S)-2-[2-(Diphenylphosphino)phenyl]-4-(tert-butyl)-2-oxazoline; (Sa,S)-tert-ButylPHOX; Chiral PHOX Ligand
EINECS	Contact for details

Quality Control

Our (Sa,S)-Dtb-Ph-Siphox is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) with full specification data are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.