Description

(S)-(-)-7[4(S)-(Benzyl)Oxazol-2-Yl]-7-Di(3,5-Di-T-Butylphenyl)Phosphino-2,23,3Tetrahydro-1,1Spirobiindane, Min. 97% (Sa,S)-Dtb-Bn-Siphox is a high-purity, chiral phosphine-oxazoline ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are essential for the efficient synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is specifically designed for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical API synthesis.
• Asymmetric C-C Bond Formation: Catalyzes critical reactions like Heck couplings, allylic alkylations, and conjugate additions with high stereoselectivity.
• Process Chemistry & Scale-Up: Used in the development and optimization of commercial-scale manufacturing routes for chiral molecules.
• Academic & Industrial R&D: A valuable tool for discovering new catalytic methodologies and exploring novel asymmetric transformations.
• Fine Chemical Synthesis: Production of enantiomerically pure flavors, fragrances, and advanced organic intermediates.
• Agrochemical Intermediate Production: Synthesis of chiral active ingredients for herbicides and pesticides.

Basic Information

Item	Details
Product Name	(S)-(-)-7[4(S)-(Benzyl)Oxazol-2-Yl]-7-Di(3,5-Di-T-Butylphenyl)Phosphino-2,23,3Tetrahydro-1,1Spirobiindane, Min. 97% (Sa,S)-Dtb-Bn-Siphox
CAS No.	1040274-10-9
Molecular Formula	C55H61NO2P
Molecular Weight	823.04 g/mol
Synonyms	(Sa,S)-DTB-Bn-SIPHOX; (S)-DTB-Bn-SIPHOX; (S)-(-)-7-[4(S)-(Benzyl)-2-oxazolinyl]-7-diphenylphosphino-2,2',3,3'-tetrahydro-1,1'-spirobi[indane]; (S)-(-)-7-[4(S)-(Benzyl)-2-oxazolinyl]-7-bis(3,5-di-tert-butylphenyl)phosphino-2,2',3,3'-tetrahydro-1,1'-spirobi[indane]; DTB-Bn-SIPHOX Ligand; SIPHOX-type ligand; Chiral phosphine-oxazoline ligand.
EINECS	Contact for details

Quality Control

Our (Sa,S)-Dtb-Bn-Siphox is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance. Each lot undergoes comprehensive analysis, including HPLC for purity and chiral assay, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air or ambient light should be avoided. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.