Description

3-Chloro-5-Fluoro-Dl-Phenylglycine is a non-natural, halogenated amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceuticals and agrochemicals. It is particularly valuable for researchers and manufacturers in the pharmaceutical industry seeking to incorporate unique steric and electronic properties into target molecules, such as enzyme inhibitors or receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Synthesis: Used as a precursor in the design of novel herbicides, fungicides, and pesticides, leveraging the halogen atoms for enhanced bioactivity.
• Peptidomimetics & Drug Discovery: Incorporated into peptide analogs to improve metabolic stability, membrane permeability, and binding affinity.
• Ligand & Catalyst Development: Serves as a scaffold for creating novel chiral ligands used in asymmetric catalysis.
• Chemical Biology Research: Employed as a probe or tool compound in biochemical studies to investigate enzyme mechanisms or protein interactions.
• Material Science: Potential monomer for the synthesis of specialized polymers with unique optical or electronic properties.

Basic Information

Product Name	3-Chloro-5-Fluoro-Dl-Phenylglycine
CAS No.	1038843-45-6
Molecular Formula	C8H7ClFNO2
Molecular Weight	203.60 g/mol
Synonyms	DL-3-Chloro-5-fluorophenylglycine; (±)-2-Amino-2-(3-chloro-5-fluorophenyl)acetic acid; 3-Chloro-5-fluoro-DL-α-aminophenylacetic acid; (3-Chloro-5-fluorophenyl)glycine; 2-(3-Chloro-5-fluorophenyl)glycine; NSC 876180; (RS)-2-Amino-2-(3-chloro-5-fluorophenyl)acetic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoro-Dl-Phenylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and potential degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	DL-Racemate
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.