Description

1-[2-(2-Chloro-6-Fluoro-Phenyl)-Cyclopropyl]-Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropyl ketone structure substituted with halogenated aromatic rings. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Serves as a building block for creating new generation pesticides and herbicides with improved efficacy.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Item	Details
Product Name	1-[2-(2-Chloro-6-Fluoro-Phenyl)-Cyclopropyl]-Ethanone
CAS No.	1038300-47-8
Molecular Formula	C11H10ClFO
Molecular Weight	212.65 g/mol
Synonyms	2-Chloro-6-fluoro-α-(1-oxoethyl)benzenepropanenitrile; 1-[2-(2-Chloro-6-fluorophenyl)cyclopropyl]ethanone; 2-Chloro-6-fluorophenyl cyclopropyl ketone derivative; (2-Chloro-6-fluorophenyl)cyclopropyl methyl ketone; α-Acetyl-2-chloro-6-fluorobenzenecyclopropane; CP-4578 (research code); FCK Intermediate
EINECS	Contact for details

Quality Control

Our 1-[2-(2-Chloro-6-Fluoro-Phenyl)-Cyclopropyl]-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with every shipment to guarantee reliable and reproducible performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.