Description

Difluoro(3-Methylphenyl)Acetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring a difluoroacetic acid moiety attached to a methylphenyl ring, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and liquid crystals, where fluorinated aromatic units modify material properties.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation reactions and the effects of fluorination.

Basic Information

Product Name	Difluoro(3-Methylphenyl)Acetic Acid
CAS No.	1038247-17-4
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	2,2-Difluoro-2-(3-methylphenyl)acetic acid; α,α-Difluoro-m-toluic acid; 3-Methyl-α,α-difluorobenzeneacetic acid; (3-Methylphenyl)difluoroacetic acid; m-Tolyl-difluoroacetic acid; Difluoro(3-methylphenyl)ethanoic acid; 1038247-17-4
EINECS	Contact for details

Quality Control

Every batch of Difluoro(3-Methylphenyl)Acetic Acid is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and GC-MS, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades or analytical specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.