Description

(E)-3-(1-(tert-Butoxycarbonyl)Piperidin-4-Yl)But-2-Enoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disease drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for creating libraries of potential drug molecules.
• Protease Inhibitor Synthesis: The piperidine core structure makes it valuable for constructing inhibitors targeting various proteases.
• Peptidomimetic Development: Employed in the design and synthesis of peptidomimetics, which are molecules that mimic peptides but with improved stability and bioavailability.
• Chemical Biology Probes: Serves as a precursor for creating labeled or tagged compounds used to study biological pathways and protein function.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	(E)-3-(1-(tert-Butoxycarbonyl)Piperidin-4-Yl)But-2-Enoic Acid
CAS No.	1037754-65-6
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	(E)-3-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-2-butenoic Acid; 3-[(E)-1-(tert-Butoxycarbonyl)piperidin-4-yl]but-2-enoic Acid; Boc-4-Piperidineacrylic Acid (E-isomer); (E)-3-(1-Boc-piperidin-4-yl)but-2-enoic Acid; 2-Butenoic acid, 3-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]-, (2E)-; tert-Butyl 4-[(1E)-3-carboxy-1-propen-1-yl]-1-piperidinecarboxylate
EINECS	Contact for details

Quality Control

Our (E)-3-(1-(tert-Butoxycarbonyl)Piperidin-4-Yl)But-2-Enoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.