Description

1-Bromo-2-Fluoro-4-(2,2,2-Trifluoroethoxy)-Benzene is a high-value, multi-functional halogenated benzene derivative designed for advanced chemical synthesis. This compound serves as a critical building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique substitution pattern enables precise structural modifications. It is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Active Ingredient Precursor: Used in the development of next-generation herbicides and fungicides with enhanced efficacy and environmental profiles.
• Liquid Crystal Material Synthesis: Serves as a core component for creating fluorinated liquid crystals used in advanced display technologies.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a building block for electron-transport or host materials in OLED devices.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine and trifluoroethoxy groups on molecular properties like lipophilicity and metabolic stability.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-Bromo-2-Fluoro-4-(2,2,2-Trifluoroethoxy)-Benzene
CAS No.	1036724-63-6
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	4-Bromo-3-fluoro-1-(2,2,2-trifluoroethoxy)benzene; 2-Fluoro-4-(2,2,2-trifluoroethoxy)bromobenzene; 1-Bromo-2-fluoro-4-(trifluoroethoxy)benzene; Benzene, 1-bromo-2-fluoro-4-(2,2,2-trifluoroethoxy)-; 2-Fluoro-4-(2,2,2-trifluoroethoxy)-1-bromobenzene; 4-(2,2,2-Trifluoroethoxy)-2-fluorobromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-4-(2,2,2-Trifluoroethoxy)-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.