Description

4-Bromo-1-Fluoro-2-(Phenylmethoxy)Benzene is a high-purity halogenated aromatic ether building block of significant interest in advanced organic synthesis. Its value lies in its versatile reactivity, where the bromo and fluoro substituents serve as orthogonal handles for selective functionalization, enabling the construction of complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex diaryl ether or fluorinated aromatic motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity often associated with fluorinated compounds.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or nitrogen-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, or organic electronic materials due to its rigid, substituted benzene core.
• Cross-Coupling Reactions: The bromine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination.
• Nucleophilic Aromatic Substitution: The activated fluorine atom adjacent to the ether oxygen allows for selective displacement with various nucleophiles.

Basic Information

Product Name	4-Bromo-1-Fluoro-2-(Phenylmethoxy)Benzene
CAS No.	1036724-54-5
Molecular Formula	C13H10BrFO
Molecular Weight	281.12 g/mol
Synonyms	1-Bromo-4-fluoro-2-(benzyloxy)benzene; 2-Benzyloxy-4-bromo-1-fluorobenzene; 4-Bromo-2-(benzyloxy)-1-fluorobenzene; 4-Bromo-1-fluoro-2-(benzyloxy)benzene; Benzene, 4-bromo-1-fluoro-2-(phenylmethoxy)-; 2-(Benzyloxy)-4-bromo-1-fluorobenzene; 4-Bromo-2-benzyloxy-1-fluorobenzene; 1-Fluoro-4-bromo-2-(phenylmethoxy)benzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Fluoro-2-(Phenylmethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard grades meet the stringent requirements for research and process development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.