Description

1-Dicyclohexylphosphino-1′-{(R)-{(Rp)-2-[(S)-1-(Dimethylamino)Ethyl]Ferrocenyl}Phenylphosphino}Ferrocene is a highly sophisticated, chiral ferrocenylphosphine ligand designed for asymmetric catalysis. This compound matters because it provides exceptional stereocontrol in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of complex chiral molecules with high enantiomeric purity. It is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries who require reliable, high-performance catalysts for producing enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral alcohols and amines.
• Cross-Coupling Reactions: Facilitates challenging asymmetric Suzuki-Miyaura, Negishi, and Buchwald-Hartwig amination reactions to construct chiral biaryl and C-N bonds.
• Pharmaceutical Intermediate Synthesis: Key catalyst in the development and scale-up of chiral drug candidates, including those for oncology, CNS disorders, and cardiovascular diseases.
• Agrochemicals and Flavors/Fragrances: Enables the production of enantiomerically pure compounds for advanced crop protection agents and specialty aroma chemicals.
• Academic and Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.
• Process Chemistry Optimization: Used to improve the efficiency, yield, and selectivity of existing catalytic processes in fine chemical manufacturing.

Basic Information

Product Name	1-Dicyclohexylphosphino-1′-{(R)-{(Rp)-2-[(S)-1-(Dimethylamino)Ethyl]Ferrocenyl}Phenylphosphino}Ferrocene
CAS No.	1036373-39-3
Molecular Formula	C46H55Fe2NP2
Molecular Weight	795.58 g/mol
Synonyms	(R,Rp,S)-JOSIPHOS SL-J009-1; (R)-1-[(S)-2-(Dimethylamino)ethyl]-1',2-bis(dicyclohexylphosphino)ferrocene; Josiphos-type ligand SL-J009-1; (R)-1-[(S)-1-(Dimethylamino)ethyl]-1',2-bis(dicyclohexylphosphino)ferrocene; (R)-1-[(S)-2-(N,N-Dimethylamino)ethyl]-1',2-bis(dicyclohexylphosphino)ferrocene; Dicyclohexyl(1-{(R)-{(Rp)-2-[(S)-1-(dimethylamino)ethyl]ferrocenyl}phenylphosphino}ferrocen-1-yl)phosphine; Chiral Ferrocenylphosphine Ligand J009.
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management protocols to ensure consistency and performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. Keep the container in a cool, dry, and well-ventilated place, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.