Description

(Cis)-3-Aminocyclobutanol CAS NO 1036260-43-1 is a high-purity, versatile chiral building block featuring both amino and hydroxyl functional groups on a strained cyclobutane ring. This unique structure makes it a critical intermediate for the synthesis of novel pharmaceuticals and advanced materials. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with potentially improved efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: The constrained cyclobutane ring is valuable for designing peptide mimics and bioisosteres in medicinal chemistry to modulate pharmacokinetic properties.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(Cis)-3-Aminocyclobutanol
CAS No.	1036260-43-1
Molecular Formula	C4H9NO
Molecular Weight	87.12 g/mol
Synonyms	cis-3-Aminocyclobutanol; (1r,3r)-3-Aminocyclobutanol; 3-Aminocyclobutanol (cis-); 3-Aminocyclobutan-1-ol; Cyclobutanol, 3-amino-, cis-; 1036260-43-1; (1R,3R)-3-Aminocyclobutan-1-ol
EINECS	Contact for details

Quality Control

Our (Cis)-3-Aminocyclobutanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.