Description

Propargyl-Peg13-Alcohol is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a hydroxyl group. This compound is a critical building block in advanced bioconjugation and click chemistry applications, enabling the precise, covalent attachment of biomolecules, drugs, or labels. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and materials science sectors who require reliable, functionalized PEG linkers for developing novel therapeutics, targeted delivery systems, and biocompatible surfaces.

Application

• Bioconjugation and Click Chemistry: Serves as a key linker for site-specific modification of proteins, peptides, and antibodies using copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Pharmaceutical Development: Used to create PEGylated drug conjugates to improve solubility, stability, and pharmacokinetic profiles of active pharmaceutical ingredients (APIs).
• Diagnostic Reagent Synthesis: Facilitates the development of fluorescent probes, biosensors, and immunoassay components by linking detection moieties to target molecules.
• Hydrogel and Biomaterial Fabrication: Acts as a cross-linking agent or functional monomer in the synthesis of smart hydrogels and biocompatible polymers for tissue engineering and drug delivery scaffolds.
• Surface Functionalization: Used to modify nanoparticles, quantum dots, and solid supports to create reactive surfaces for further chemical immobilization.
• ADC (Antibody-Drug Conjugate) Linker: Provides a stable, cleavable, or non-cleavable spacer between the antibody and the cytotoxic payload in ADC design.
• Oligonucleotide Labeling: Enables the attachment of reporter groups or other functional units to oligonucleotides for genetic analysis and therapeutic applications.
• Polymer Chemistry: Employed as a macroinitiator or functional chain-transfer agent in controlled radical polymerization to synthesize well-defined block copolymers.

Basic Information

Product Name	Propargyl-Peg13-Alcohol
CAS No.	1036204-61-1
Molecular Formula	C31H60O14
Molecular Weight	656.8 g/mol
Synonyms	Propargyl-PEG13-OH; α-Propargyl-ω-hydroxy-triethylene glycol undecaethylene glycol ether; 2,5,8,11,14,17,20,23,26,29,32,35,38-Tridecaoxatetracont-39-yn-1-ol; Propargyl-PEG13-alcohol; mPEG13-Propargyl; Propargyl-PEG 550 Alcohol; Propargyl-PEG 13; Alkyne-PEG13-OH
EINECS	Contact for details

Quality Control

Our Propargyl-Peg13-Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, functional group integrity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Functional Group Integrity	≥ 90% (by NMR)
Molecular Weight (SEC)	600 - 720 g/mol
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.