Description

Propargyl-Peg5-Alcohol CAS NO 1036204-60-0 is a bifunctional polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a hydroxyl group. This compound is a crucial intermediate in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the efficient and modular synthesis of complex molecules and bioconjugates. It is primarily utilized by researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science for creating PEGylated linkers, prodrugs, and functionalized surfaces.

Application

• Bioconjugation and PEGylation: Serves as a key linker for attaching drugs, peptides, or fluorescent dyes to biomolecules like antibodies and proteins via click chemistry.
• Pharmaceutical Research: Used in the synthesis of prodrugs and antibody-drug conjugates (ADCs) to improve solubility, stability, and pharmacokinetic profiles.
• Materials Science: Functionalizes surfaces, nanoparticles, and polymers to introduce hydrophilic PEG chains and reactive alkyne handles for further modification.
• Chemical Biology & Proteomics: Acts as a tool compound for labeling and studying biological processes in live cells through bioorthogonal chemistry.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents and diagnostic probes for imaging applications.
• Cross-linking Agent: Used to create hydrogels and polymer networks with tailored properties for drug delivery and tissue engineering.

Basic Information

Product Name	Propargyl-Peg5-Alcohol
CAS No.	1036204-60-0
Molecular Formula	C16H30O7
Molecular Weight	334.41 g/mol
Synonyms	2,5,8,11,14-Pentaoxaheptadec-16-yn-1-ol; Propargyl-PEG5-OH; 17-Prop-2-yn-1-yloxy-3,6,9,12,15-pentaoxaheptadecan-1-ol; Propargyl alcohol-PEG5; 5-Amino-3-oxapentyl 2-prop-2-yn-1-yloxyethyl ether; Alkyne-PEG5-alcohol; m-PEG5-propargyl alcohol; Propargyl-O-(CH2CH2O)5-H
EINECS	Contact for details

Quality Control

Our Propargyl-Peg5-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.