Description

Minocycline-D-6 CAS NO 1036070-10-6 is a deuterium-labeled analog of the broad-spectrum tetracycline antibiotic minocycline. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry-based analyses, ensuring high accuracy and reproducibility. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Internal Standard for Bioanalysis: Used in LC-MS/MS and GC-MS methods for the precise quantification of minocycline in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Metabolite Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Facilitates the identification and quantification of minocycline metabolites in in vitro and in vivo studies.
• Pharmaceutical Quality Control: Serves as a reference standard in the assay and impurity profiling of minocycline active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Anti-Doping Analysis: Provides a reliable isotopic standard for confirmatory testing in forensic toxicology and sports anti-doping programs.
• Environmental Fate Studies: Applied in research investigating the environmental persistence and breakdown of pharmaceutical compounds.

Basic Information

Product Name	Minocycline-D-6
CAS No.	1036070-10-6
Molecular Formula	C₂₃H₂₁D₆N₃O₇
Molecular Weight	467.49 g/mol
Synonyms	Minocycline-d6; (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide-d6; 7-Dimethylamino-6-demethyl-6-deoxytetracycline-d6; Deuterated Minocycline; Minocycline Internal Standard; Minocycline-d6 (hexadeuterated)
EINECS	Contact for details

Quality Control

Our Minocycline-D-6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.