Description

1-Bromo-3-Benzyloxy-4,5-Difluorobenzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its core value lies in its unique substitution pattern, offering a reactive bromine site and a protected benzyloxy group on a difluorinated benzene ring, which is crucial for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where the difluorobenzene moiety is a critical structural feature.
• Liquid Crystal & OLED Material Research: Serves as a building block for advanced electronic materials, including ligands for metal-organic frameworks (MOFs) and components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Exploration: A valuable reagent for studying the effects of fluorine substitution on aromatic systems and for further functionalization via halogen exchange (Halex) reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-value intermediates.

Basic Information

Product Name	1-Bromo-3-Benzyloxy-4,5-Difluorobenzene
CAS No.	1035155-54-4
Molecular Formula	C₁₃H₉BrF₂O
Molecular Weight	299.11 g/mol
Synonyms	3-Benzyloxy-1-bromo-4,5-difluorobenzene; 4,5-Difluoro-3-benzyloxybromobenzene; 1-Bromo-3-(benzyloxy)-4,5-difluorobenzene; Benzene, 1-bromo-3-(benzyloxy)-4,5-difluoro-; 4,5-Difluoro-3-phenmethoxybromobenzene; Bromobenzene, 3-benzyloxy-4,5-difluoro-; (3-Benzyloxy-4,5-difluorophenyl)bromide
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Benzyloxy-4,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to potential moisture sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.