Description

2-(2,2,2-Trifluoroethoxy)-1-Ethanamine Hydrochloride is a specialized organic salt featuring a trifluoroethoxy side chain, which imparts unique physicochemical properties critical for advanced chemical synthesis. This compound serves as a valuable building block in pharmaceutical research and development, particularly for introducing fluorine-containing motifs to modulate the biological activity and metabolic stability of target molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to innovate with fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel active pharmaceutical ingredients (APIs), especially in CNS and oncology research where fluorination is a common strategy.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that benefit from the enhanced lipophilicity and stability provided by the trifluoroethoxy group.
• Ligand and Catalyst Development: Acts as a precursor for nitrogen-containing ligands used in transition metal catalysis for fine chemical production.
• Peptide Modification: Employed to introduce fluorinated ether functionalities into peptides and peptidomimetics to alter their conformational and binding properties.
• Material Science Research: Serves as a monomer or modifier in the synthesis of specialty polymers and coatings with specific surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)-1-Ethanamine Hydrochloride
CAS No.	1035041-75-8
Molecular Formula	C4H9ClF3NO
Molecular Weight	191.57 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)ethan-1-amine hydrochloride; 2-(2,2,2-Trifluoroethoxy)ethylamine hydrochloride; 1-Amino-2-(2,2,2-trifluoroethoxy)ethane hydrochloride; N-(2-Trifluoroethoxyethyl)amine hydrochloride; 2-Trifluoroethoxyethylamine HCl; TFEA-HCl; 1035041-75-8
EINECS	Contact for details

Quality Control

Our 2-(2,2,2-Trifluoroethoxy)-1-Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.