Description

3,3-Difluoro-2,2-Dimethyl-1-Indanone is a high-purity fluorinated indanone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique reactivity imparted by the difluoro and gem-dimethyl groups adjacent to the ketone, enabling precise structural modifications in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require specialized building blocks for developing new active ingredients and functional materials.

Application

3,3-Difluoro-2,2-Dimethyl-1-Indanone is a versatile synthon used in the development of sophisticated chemical entities. Its primary applications include:

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in creating advanced active ingredients for crop protection, leveraging the fluorine atoms to enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, fluorinated structure.
• Chemical Biology Probes: Serves as a core scaffold for designing enzyme inhibitors and molecular probes to study biological pathways.
• Asymmetric Synthesis: Utilized in chiral synthesis protocols to introduce quaternary carbon centers and fluorinated motifs into target molecules.

Basic Information

Item	Detail
Product Name	3,3-Difluoro-2,2-Dimethyl-1-Indanone
CAS No.	1034921-55-5
Molecular Formula	C11H10F2O
Molecular Weight	196.19 g/mol
Synonyms	1-Indanone, 3,3-difluoro-2,2-dimethyl-; 3,3-Difluoro-2,2-dimethylindan-1-one; 2,2-Dimethyl-3,3-difluoro-1-indanone; 3,3-Difluoro-2,2-dimethyl-1H-inden-1-one; DFDMIO; Difluorodimethylindanone
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-2,2-Dimethyl-1-Indanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) that detail specifications including assay, impurity profiles, and residual solvents. Our quality commitment supports applications requiring high standards, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.