Description

(R,S)-N2-Nitroso-Anabasine N'-β-D-Glucuronide CAS NO 1033078-12-4 is a high-purity, specialized reference standard and analytical reagent. This compound is of critical importance for research and quality control in toxicology and metabolism studies, particularly for the analysis of tobacco-specific nitrosamines (TSNAs) and their metabolites. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in biomarker research, method development, and regulatory compliance testing.

Application

• Biomarker Reference Standard: Used as a certified reference material for the accurate quantification of anabasine-derived nitrosamine metabolites in biological matrices such as urine and plasma.
• Toxicology Research: Essential for studying the metabolism, distribution, and excretion profiles of tobacco-specific nitrosamines (TSNAs) in preclinical and clinical research.
• Analytical Method Development: Serves as a critical calibrant and system suitability standard in LC-MS/MS and HPLC-UV method development and validation for nitrosamine analysis.
• Regulatory Compliance Testing: Supports testing protocols to meet stringent regulatory requirements for nitrosamine impurity assessment in pharmaceuticals and consumer products.
• Metabolite Identification: Aids in the structural confirmation and identification of Phase II glucuronidated metabolites in drug metabolism and pharmacokinetics (DMPK) studies.

Basic Information

Item	Details
Product Name	(R,S)-N2-Nitroso-Anabasine N'-β-D-Glucuronide
CAS No.	1033078-12-4
Molecular Formula	C22H29N3O8
Molecular Weight	463.48 g/mol
Synonyms	N'-Nitrosoanabasine-β-D-Glucuronide; N-Nitrosoanabasine N-Glucuronide; (R,S)-N'-Nitrosoanabasine N'-β-D-Glucopyranosiduronic Acid; NAB-Gluc; N-Nitrosoanabasine Glucuronide; Anabasine N-Nitroso Metabolite Glucuronide; TSNA Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of (R,S)-N2-Nitroso-Anabasine N'-β-D-Glucuronide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure identity, purity, and stability. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee compliance with research and analytical standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, store at 2-8°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The container should be kept in a dry, well-ventilated area designated for laboratory chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.