Description

1-(1,1-Difluoroethyl)-2-Iodobenzene is a high-value, multi-functional halogenated aromatic building block designed for advanced synthetic chemistry. Its unique structure, featuring both iodine and difluoroethyl groups, makes it an essential intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily utilized by R&D chemists and process development scientists in the life sciences sector for applications such as cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the difluoroethyl moiety can enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with unique electronic properties.
• Cross-Coupling Reactions: The aryl iodide moiety is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Sonogashira, Heck) for carbon-carbon bond formation.
• Fluorine Chemistry: Acts as a valuable source of a difluoroethyl group for introducing fluorine atoms into target molecules to modulate lipophilicity and bioavailability.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for catalysis and molecular recognition studies.

Basic Information

Product Name	1-(1,1-Difluoroethyl)-2-Iodobenzene
CAS No.	1032507-55-3
Molecular Formula	C8H7F2I
Molecular Weight	268.05 g/mol
Synonyms	2-Iodo-1-(1,1-difluoroethyl)benzene; 1-(1,1-Difluoroethyl)-2-iodobenzene; o-Iodo-α,α-difluoroethylbenzene; 2-Iodo-α,α-difluoroethylbenzene; Benzene, 1-(1,1-difluoroethyl)-2-iodo-; 1-Difluoroethyl-2-iodobenzene
EINECS	Contact for details

Quality Control

Our 1-(1,1-Difluoroethyl)-2-Iodobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ISO 9001 standards and can provide material suitable for use under cGMP guidelines for non-clinical research stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.