Description

tert-Butyl 1-(4-Cyanophenyl)Cyclobutylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclobutyl and carbamate-protected amine structure. This compound is of significant value in medicinal chemistry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in process development and scale-up.

Application

• Key Intermediate in API Synthesis: Serves as a critical building block in the multi-step synthesis of complex drug candidates.
• Medicinal Chemistry Research: Used in research laboratories for structure-activity relationship (SAR) studies and lead optimization.
• Process Development & Scale-up: Employed in the development and optimization of robust, scalable synthetic routes for pharmaceutical manufacturing.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) protecting group allows for selective manipulation of the amine functionality during complex syntheses.
• Precursor for Further Functionalization: The 4-cyanophenyl moiety provides a handle for further chemical transformations, such as reduction to an aminomethyl group or conversion to other functional groups.

Basic Information

Product Name	tert-Butyl 1-(4-Cyanophenyl)Cyclobutylcarbamate
CAS No.	1032349-97-5
Molecular Formula	C16H20N2O2
Molecular Weight	272.34 g/mol
Synonyms	1-(4-Cyanophenyl)cyclobutanamine, N-Boc derivative; BOC-1-(4-Cyanophenyl)cyclobutanamine; tert-Butyl [1-(4-cyanophenyl)cyclobutyl]carbamate; 1-(4-Cyanophenyl)cyclobutanamine, 1,1-dimethylethyl carbamate; 1,1-Dimethylethyl N-[1-(4-cyanophenyl)cyclobutyl]carbamate; 1-(4-Cyanophenyl)cyclobutylcarbamic acid tert-butyl ester; (1-(4-Cyanophenyl)cyclobutyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(4-Cyanophenyl)Cyclobutylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged exposure to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.