Description

Linezolid-D8 is a deuterated analog of the synthetic antibiotic linezolid, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for the precise quantification of linezolid in complex biological matrices using advanced analytical techniques. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioanalytical method development, and drug metabolism research. The high isotopic purity and chemical stability ensure reliable and reproducible results in sensitive mass spectrometry-based assays.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of linezolid in plasma, serum, and tissue samples.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Used as a reference material to develop, optimize, and validate robust bioanalytical assays in compliance with GLP and FDA/EMA guidelines.
• Drug Impurity Profiling: Aids in the identification and quantification of metabolites or degradation products in stability studies.
• Forensic & Toxicology Testing: Supports accurate measurement of linezolid concentrations in forensic and clinical toxicology applications.
• Quality Control in Manufacturing: Can be utilized as a system suitability standard in the quality control of linezolid active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Product Name	Linezolid-D8
CAS No.	1032182-14-1
Molecular Formula	C16H12D8F3N3O4
Molecular Weight	345.33 g/mol (approximate)
Synonyms	(S)-N-({3-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide-D8; Linezolid (phenyl-D5, acetyl-D3); Perdeuterated Linezolid; Linezolid-d8; Zyvox-D8; PNU-100766-D8; Deuterated Linezolid Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Linezolid-D8 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment supports research requiring traceable and reliable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.