Description

Phenobarbital n-β-D-Glucuronide CAS NO 1031858-68-0 is a high-purity reference standard and metabolite of the barbiturate drug phenobarbital. This compound is critical for analytical research and quality control in pharmaceutical development and forensic toxicology. It is primarily used by analytical laboratories, pharmaceutical R&D departments, and regulatory agencies for method validation, calibration, and metabolite identification studies.

Application

• Pharmaceutical Reference Standard: Used for the quantitative and qualitative analysis of phenobarbital and its metabolites in drug substance and product testing.
• Metabolite Profiling & Pharmacokinetics: Essential for studying the metabolism, distribution, and excretion of phenobarbital in preclinical and clinical research.
• Forensic & Clinical Toxicology: Serves as a certified reference material for the accurate detection and confirmation of phenobarbital use in biological samples (e.g., blood, urine).
• Method Development & Validation: A key component in developing and validating robust analytical methods, particularly using HPLC, LC-MS, and GC-MS techniques.
• Quality Control (QC) & Quality Assurance (QA): Employed in internal and external laboratory QC protocols to ensure accuracy and compliance with regulatory standards.
• Biochemical Research: Used in studies investigating glucuronidation pathways and enzyme activity related to drug metabolism.

Basic Information

Product Name	Phenobarbital n-β-D-Glucuronide
CAS No.	1031858-68-0
Molecular Formula	C23H26N2O10
Molecular Weight	490.46 g/mol
Synonyms	Phenobarbital β-D-Glucuronide; Phenobarbital Glucuronide; 5-Ethyl-5-phenylbarbituric acid β-D-glucuronide; Phenobarbital N-Glucuronide; Luminal Glucuronide; Phenobarbitone Glucuronide; 5-Ethyl-5-phenyl-1-(β-D-glucopyranuronosyl)-1,3-diazinane-2,4,6-trione
EINECS	Contact for details

Quality Control

Our Phenobarbital n-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assessment and structural confirmation, to ensure it meets the high standards required for reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.