Description

4-Carboxy-2,6-Difluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound is a critical protected intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex biaryl structures found in advanced materials and pharmaceuticals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing difluorinated biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the difluorophenyl moiety imparts desirable biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or precursor for creating advanced organic electronic materials, such as OLEDs, OFETs, and conductive polymers.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis or as a scaffold in metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Can be used to create chemical probes or affinity tags for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the global life sciences sector.

Basic Information

Product Name	4-Carboxy-2,6-Difluorophenylboronic Acid Pinacol Ester
CAS No.	1031857-96-1
Molecular Formula	C14H17BF2O4
Molecular Weight	298.10 g/mol
Synonyms	2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluorobenzoic Acid; 2,6-Difluoro-4-carboxyphenylboronic Acid Pinacol Ester; 4-Borono-2,6-difluorobenzoic Acid Pinacol Ester; 2,6-Difluoro-4-pinacolatoborylbenzoic Acid; (4-Carboxy-2,6-difluorophenyl)boronic Acid Pinacol Ester; B-(4-Carboxy-2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 4-Carboxy-2,6-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high chemical purity and lot-to-lot consistency to meet the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing purity (by HPLC/NMR), identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential hydrolysis. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.