Description

Losartan-D4 is a stable isotope-labeled analog of the widely prescribed antihypertensive drug Losartan, specifically deuterated at four positions. This high-purity compound is an essential internal standard for the precise and accurate quantification of Losartan in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical research and development, clinical laboratories, and regulatory agencies engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research. The product is supplied under stringent quality control to ensure reliability and reproducibility in sensitive analytical applications.

Application

• Internal Standard for Bioanalysis: Primary use as a deuterated internal standard in the quantitative LC-MS/MS analysis of Losartan in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling: Used in method development and validation for identifying and quantifying process-related impurities and degradants.
• Forensic & Clinical Toxicology: Supports accurate measurement of Losartan levels in therapeutic drug monitoring and forensic investigations.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating test methods.
• Stable Isotope Labeling Studies: Utilized in metabolic pathway elucidation and proteomics research where isotopic labeling is required.

Basic Information

Product Name	Losartan-D4
CAS No.	1030937-27-9
Molecular Formula	C22H19D4ClN6O
Molecular Weight	428.94 g/mol
Synonyms	Losartan-d4; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol-d4; DuP 753-d4; MK 954-d4; (2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol-d4; Cozaar-d4 (labeled analog)
EINECS	Contact for details

Quality Control

Our Losartan-D4 is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analysis to ensure high chemical and isotopic purity, meeting the exacting standards required for analytical reference materials. Specifications typically include confirmation of identity, assay by HPLC, determination of isotopic enrichment (D4), and limits for related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.