Description

2-Methyl-5-Trifluoromethylphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its pinacol ester group provides enhanced stability and handling characteristics compared to the free boronic acid, making it a superior reagent for demanding applications. This compound is a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the valuable 2-methyl-5-trifluoromethylphenyl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable and efficient organoboron reagent in palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis and as a precursor for functional materials.
• Advanced Material Research: Used in the synthesis of organic electronic materials, liquid crystals, and polymers where the specific aromatic substitution pattern is required.
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds and molecular probes for diagnostic and research applications.

Basic Information

Product Name	2-Methyl-5-Trifluoromethylphenylboronic Acid, Pinacol Ester
CAS No.	1030832-71-3
Molecular Formula	C14H18BF3O2
Molecular Weight	286.10 g/mol
Synonyms	2-Methyl-5-(trifluoromethyl)benzeneboronic Acid Pinacol Ester; 2-Methyl-α,α,α-trifluoro-m-tolueneboronic Acid Pinacol Ester; (2-Methyl-5-(trifluoromethyl)phenyl)boronic Acid Pinacol Ester; 5-Trifluoromethyl-2-methylphenylboronic Acid Pinacol Ester; 2-Methyl-5-trifluoromethylphenylboronic Acid Pinanediol Ester; B-(2-Methyl-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1030832-71-3
EINECS	Contact for details

Quality Control

Our 2-Methyl-5-Trifluoromethylphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to consistent quality and supply chain reliability makes us a trusted partner for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.