Description

2-(2-(Bromomethyl)-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a boronic ester, critical for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for diagnostic and research applications.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the (5-fluoro-2-(bromomethyl)phenyl) fragment into target molecules.
• Medicinal Chemistry: Enables rapid parallel synthesis and structure-activity relationship (SAR) studies by providing a versatile handle for diversification.

Basic Information

Product Name	2-(2-(Bromomethyl)-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1030832-39-3
Molecular Formula	C₁₃H₁₇BBrFO₂
Molecular Weight	329.99 g/mol
Synonyms	(5-Fluoro-2-(bromomethyl)phenyl)boronic acid pinacol ester; 2-(2-(Bromomethyl)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Bromomethyl-5-fluorophenyl)boronic acid pinacol ester; 5-Fluoro-2-(bromomethyl)benzeneboronic acid pinacol ester; 1-Bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluorobenzene; CAS 1030832-39-3
EINECS	Contact for details

Quality Control

Our 2-(2-(Bromomethyl)-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements, supporting compliance in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.