Description

3,5-Difluoro-4-Carboxyphenylboronic Acid is a multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a boronic acid group for Suzuki-Miyaura cross-coupling reactions and a carboxylic acid moiety for further derivatization, all on a difluorinated aromatic scaffold. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides that benefit from the difluorophenyl motif.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Utilized in the development of chemical probes, sensors, and affinity ligands that target proteins or carbohydrates.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality makes it a versatile coupling partner for creating biaryl and heterobiaryl structures central to many functional compounds.
• Further Functionalization: The carboxylic acid group allows for easy conversion to amides, esters, and other derivatives, expanding its utility in combinatorial chemistry libraries.

Basic Information

Item	Detail
Product Name	3,5-Difluoro-4-Carboxyphenylboronic Acid
CAS No.	1029716-94-6
Molecular Formula	C7H5BF2O4
Molecular Weight	201.92 g/mol
Synonyms	4-Borono-2,6-difluorobenzoic Acid; (4-Carboxy-2,6-difluorophenyl)boronic Acid; 2,6-Difluoro-4-carboxyphenylboronic Acid; 3,5-Difluoro-4-carboxybenzeneboronic Acid; B-(3,5-Difluoro-4-carboxyphenyl)boronic Acid; 3,5-Difluoro-4-boronobenzoic Acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Carboxyphenylboronic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.