Description

4-Carboxy-2,3-Difluorophenylboronic Acid is a multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a boronic acid handle for Suzuki-Miyaura cross-coupling and a carboxylic acid group for further derivatization, enabling the construction of complex, fluorinated molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and advanced materials where precise fluorine substitution is required.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that benefit from fluorinated aromatic systems for enhanced bioactivity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and other advanced catalytic processes.
• Material Science Research: Employed in the synthesis of fluorinated organic electronic materials, such as those for OLEDs and semiconductors.
• Chemical Biology Probes: Useful for synthesizing fluorinated probes and tags for studying biological systems and protein interactions.
• Custom Synthesis and Scale-up: Supplied for contract research organizations (CROs) and development and manufacturing organizations (CDMOs) for custom synthesis projects from milligram to kilogram scale.

Basic Information

Product Name	4-Carboxy-2,3-Difluorophenylboronic Acid
CAS No.	1029716-92-4
Molecular Formula	C7H5BF2O4
Molecular Weight	201.93 g/mol
Synonyms	2,3-Difluoro-4-boronobenzoic Acid; (4-Carboxy-2,3-difluorophenyl)boronic Acid; 4-Borono-2,3-difluorobenzoic Acid; 2,3-Difluoro-4-carboxyphenylboronic Acid; B-(4-Carboxy-2,3-difluorophenyl)boronic Acid; 1029716-92-4; 4-Carboxy-2,3-difluorobenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 4-Carboxy-2,3-Difluorophenylboronic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.