Description

3,5-Difluoro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenol is a high-value boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that benefit from the stability and reactivity of the boronate ester group.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units are desirable.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and molecular recognition.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A vital reagent for CROs and CDMOs offering bespoke chemical synthesis services to global clients.

Basic Information

Product Name	3,5-Difluoro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenol
CAS No.	1029439-87-9
Molecular Formula	C12H15BF2O3
Molecular Weight	256.06 g/mol
Synonyms	2-(3,5-Difluoro-4-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-difluorophenol; 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; Phenol, 3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3,5-Difluoro-4-hydroxyphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.