Description

2,3-Difluoro-4-Hydroxyphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex fluorinated aromatic structures. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the difluorophenol moiety imparts desirable biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated aromatic cores in advanced electronic materials, enhancing performance and stability.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and functional materials requiring precise fluorinated aromatic linkages.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on organofluorine chemistry and new synthetic methodologies.
• Diagnostic Agent Precursor: Potential use in synthesizing fluorinated compounds for imaging agents and diagnostic tools.

Basic Information

Product Name	2,3-Difluoro-4-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	1029439-85-7
Molecular Formula	C12H15BF2O3
Molecular Weight	256.06 g/mol
Synonyms	2,3-Difluoro-4-hydroxybenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2,3-difluoro-4-hydroxyphenyl)-1,3,2-dioxaborolane; (2,3-Difluoro-4-hydroxyphenyl)boronic acid pinacol ester; Pinacol (2,3-difluoro-4-hydroxyphenyl)boronate; 2-(2,3-Difluoro-4-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.