Description

α-Amino-2-(Ethoxycarbonyl)-1-Azetidinebutanoic Acid Ethyl Ester Hydrochloride is a high-purity, non-natural amino acid derivative and a key chiral building block in advanced organic synthesis. Its primary value lies in its complex azetidine ring structure, which is crucial for constructing novel pharmacophores with enhanced biological activity and metabolic stability. This intermediate is essential for research and development chemists in the pharmaceutical industry, particularly for the synthesis of protease inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new chemical entities (NCEs), particularly in protease inhibitor programs.
• Peptidomimetics: Used to construct constrained peptide analogs where the azetidine ring introduces conformational rigidity, improving potency and selectivity.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• API Development: Employed in the synthetic route development and scale-up of active pharmaceutical ingredients (APIs) requiring complex, stereodefined amino acid components.
• Bioconjugation Chemistry: Potential use in creating linkers or payloads for antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring novel heterocyclic chemistry and bioorganic synthesis.

Basic Information

Product Name	α-Amino-2-(Ethoxycarbonyl)-1-Azetidinebutanoic Acid Ethyl Ester Hydrochloride
CAS No.	1028192-80-4
Molecular Formula	C13H22N2O5 • HCl
Molecular Weight	322.79 g/mol (Free base: 286.33 g/mol)
Synonyms	Ethyl (2S)-2-Amino-4-[(2S)-2-(ethoxycarbonyl)azetidin-1-yl]butanoate Hydrochloride; (2S)-2-Amino-4-[(2S)-2-(ethoxycarbonyl)-1-azetidinyl]butanoic Acid Ethyl Ester Hydrochloride; 1-Azetidinebutanoic Acid, α-amino-2-(ethoxycarbonyl)-, Ethyl Ester, Hydrochloride, (2S,2'S)-; L-α-Amino-2-(ethoxycarbonyl)-1-azetidinebutanoic Acid Ethyl Ester HCl; Azetidine Amino Ester Hydrochloride; CAS 1028192-80-4
EINECS	Contact for details

Quality Control

Our α-Amino-2-(Ethoxycarbonyl)-1-Azetidinebutanoic Acid Ethyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing full characterization data—including assay, enantiomeric excess, and impurity profile—is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.