Description

Difluoro-(3-Fluoro-4-Methylphenyl)Acetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where fluorine substitution enhances efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in advanced display technologies.
• Polymer Chemistry: Acts as a monomer or modifier for introducing fluorine into polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Electronic Materials: Employed in the synthesis of fluorinated semiconductors and charge-transport materials for OLEDs and OFETs.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and creating novel chemical entities in academic and industrial R&D labs.

Basic Information

Product Name	Difluoro-(3-Fluoro-4-Methylphenyl)Acetic Acid
CAS No.	1027514-20-0
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	2,2-Difluoro-2-(3-fluoro-4-methylphenyl)acetic acid; (3-Fluoro-4-methylphenyl)difluoroacetic acid; α,α-Difluoro-3-fluoro-4-methylbenzeneacetic acid; 2-(3-Fluoro-4-methylphenyl)-2,2-difluoroacetic acid; DF-(3-F-4-MePh)AA; 1027514-20-0; Difluoro(3-fluoro-4-methylphenyl)ethanoic acid
EINECS	Contact for details

Quality Control

Our Difluoro-(3-Fluoro-4-Methylphenyl)Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR, IR, and MS. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.