Description

Ethyl-2,2-Difluoro-2-(3-Chloro-4-Fluorophenyl)Acetate is a high-purity fluorinated and chlorinated aromatic ester building block, essential for advanced synthetic chemistry. Its unique difluoroacetate moiety adjacent to a halogenated phenyl ring makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and liquid crystals, imparting unique solubility and thermal properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Negishi couplings, to introduce the (3-chloro-4-fluorophenyl)difluoroacetate group into complex molecular architectures.
• Fluorine Chemistry Research: A valuable substrate for studying the reactivity of gem-difluoro compounds and for developing new fluorination methodologies.

Basic Information

Product Name	Ethyl-2,2-Difluoro-2-(3-Chloro-4-Fluorophenyl)Acetate
CAS No.	1027514-18-6
Molecular Formula	C10H8ClF3O2
Molecular Weight	252.62 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-Chloro-4-fluorophenyl)acetate; 2-(3-Chloro-4-fluorophenyl)-2,2-difluoroacetic Acid Ethyl Ester; (3-Chloro-4-fluorophenyl)difluoroacetic Acid Ethyl Ester; Ethyl (3-Chloro-4-fluorophenyl)difluoroacetate; Acetic acid, 2-(3-chloro-4-fluorophenyl)-2,2-difluoro-, ethyl ester; Ethyl α,α-Difluoro-3-chloro-4-fluorophenylacetate
EINECS	Contact for details

Quality Control

Our Ethyl-2,2-Difluoro-2-(3-Chloro-4-Fluorophenyl)Acetate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.