Description

2,2-Difluoro-2-(3-Chlorophenyl)Acetic Acid is a high-value fluorinated aromatic building block, essential for introducing difluoroacetic acid motifs into complex molecular architectures. Its primary commercial value lies in serving as a critical intermediate in the synthesis of advanced pharmaceutical compounds and agrochemicals, where the difluoro group can significantly alter biological activity and metabolic stability. This compound is particularly sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery and development programs targeting metabolic diseases, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances lipophilicity and systemic activity.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and advanced materials with unique chemical resistance or surface properties.
• Ligand and Catalyst Development: Employed in organic and medicinal chemistry research for creating novel chiral ligands, organocatalysts, or metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and for introducing fluorinated segments into complex molecules in academic and industrial R&D settings.

Basic Information

Product Name	2,2-Difluoro-2-(3-Chlorophenyl)Acetic Acid
CAS No.	1027513-91-2
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	3-Chloro-α,α-difluorobenzeneacetic Acid; (3-Chlorophenyl)difluoroacetic Acid; 2,2-Difluoro-2-(3-chlorophenyl)ethanoic Acid; α,α-Difluoro-3-chlorophenylacetic Acid; 3-Chloro-α,α-difluorophenylacetic Acid; Difluoro(3-chlorophenyl)acetic Acid; 1027513-91-2
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-(3-Chlorophenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.