Description

Cyclopentyl-Difluoroacetic Acid CAS NO 1027513-89-8 is a specialized fluorinated organic acid building block, characterized by its cyclopentyl ring and difluoroacetic acid moiety. This unique structure makes it a valuable intermediate for synthesizing novel compounds with enhanced metabolic stability and lipophilicity, which are critical properties in advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating next-generation active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting protease inhibitors and other enzyme modulators where the difluoroacetate group is utilized as a bioisostere.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, where the fluorine atoms and cyclopentyl group can improve compound activity, selectivity, and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and other specialty materials that require specific dielectric properties or chemical resistance.
• Chemical Biology Probes: Useful for synthesizing activity-based probes and labeled compounds for studying biochemical pathways and protein function.

Basic Information

Product Name	Cyclopentyl-Difluoroacetic Acid
CAS No.	1027513-89-8
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	2,2-Difluoro-2-cyclopentylacetic Acid; Cyclopentyl(difluoro)acetic Acid; 2-Cyclopentyl-2,2-difluoroacetic Acid; (Cyclopentyl)difluoroethanoic Acid; α,α-Difluorocyclopentaneacetic Acid; Difluoro(cyclopentyl)acetic Acid; Cyclopentanemethanecarboxylic Acid, α,α-difluoro-; 1027513-89-8 (CAS)
EINECS	Contact for details

Quality Control

Our Cyclopentyl-Difluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the consistency and reliability required for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 2°C and 8°C for long-term stability. The product is moisture-sensitive; keep container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.