Description

1-Bromo-2-(2,2,2-trifluoroethyl)-benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique combination of a reactive bromine substituent and a trifluoroethyl group, which introduces desirable physicochemical properties into target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoroethyl motifs for enhanced metabolic stability, lipophilicity, or bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), influencing dielectric anisotropy and emission properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl and extended conjugated systems.
• Fluorinated Polymer Monomers: Employed in the research and production of specialty polymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Radiotracer & Diagnostic Agent Precursor: Potential use in the synthesis of fluorinated compounds for positron emission tomography (PET) imaging and other diagnostic applications.

Basic Information

Item	Details
Product Name	1-Bromo-2-(2,2,2-Trifluoroethyl)-Benzene
CAS No.	1027513-81-0
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	2-(2-Bromophenyl)-1,1,1-trifluoroethane; 1-Bromo-2-(2,2,2-trifluoroethyl)benzene; o-Bromo(2,2,2-trifluoroethyl)benzene; 2-(2,2,2-Trifluoroethyl)bromobenzene; [2-Bromophenyl](trifluoromethyl)methane; α,α,α-Trifluoro-2-bromoethylbenzene
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-2-(2,2,2-trifluoroethyl)-benzene adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP and ISO quality management principles for regulated market supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Purity (HPLC)	≥ 96.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.