Description

(R)-3,3-Difluoropropane-1,2-Diol CAS NO 1026908-13-3 is a high-value chiral fluorinated building block, essential for introducing the difluoromethylene ether bioisostere into complex molecules. Its primary commercial value lies in enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the development of next-generation therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides and fungicides, leveraging fluorine's ability to modulate lipophilicity and biological activity.
• Material Science: Precursor for specialty polymers and liquid crystals where fluorine content imparts unique chemical resistance and optical properties.
• PET Tracer Development: Used in radiochemistry for creating fluorine-18 labeled probes for positron emission tomography (PET) imaging.
• Asymmetric Catalysis Research: Valuable substrate for developing and testing new chiral catalysts and methodologies.
• Bioconjugation: Enables the site-specific modification of peptides and proteins via its diol functionality.

Basic Information

Product Name	(R)-3,3-Difluoropropane-1,2-Diol
CAS No.	1026908-13-3
Molecular Formula	C3H6F2O2
Molecular Weight	112.08 g/mol
Synonyms	(R)-3,3-Difluoro-1,2-propanediol; (R)-3,3-Difluoropropylene Glycol; (2R)-3,3-Difluoropropane-1,2-diol; (R)-1,2-Dihydroxy-3,3-difluoropropane; (R)-DFPG; (R)-3,3-DFPD; (R)-Difluoropropanediol
EINECS	Contact for details

Quality Control

Our (R)-3,3-Difluoropropane-1,2-Diol is manufactured under strict quality management systems. Each batch is characterized and tested to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical R&D. Comprehensive analytical methods including chiral HPLC, NMR, and GC are employed. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability due to its hygroscopic (moisture-sensitive) nature. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.