Description

n-Fmoc-4-Fluorobenzyl-Glycine is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it enables the precise incorporation of a fluorobenzyl-protected glycine residue. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs) for targeted therapies.
• Bioconjugation: Serves as a linker or functional handle for attaching peptides to other molecules, surfaces, or probes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of enzyme inhibitors.
• Peptide Library Construction: Facilitates the creation of diverse peptide libraries for high-throughput screening in drug discovery.
• Fluorinated Peptide Analogues: Enables the synthesis of peptides containing fluorinated aromatic side chains to modulate stability, bioavailability, and receptor binding.

Basic Information

Product Name	n-Fmoc-4-Fluorobenzyl-Glycine
CAS No.	1026539-56-9
Molecular Formula	C24H20FNO4
Molecular Weight	405.42 g/mol
Synonyms	Fmoc-4-F-Bzl-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluorobenzyl-glycine; N-Fmoc-N-(4-fluorobenzyl)glycine; (2-(((9H-Fluoren-9-yl)methoxy)carbonyl)((4-fluorophenyl)methyl)amino)acetic acid; Fmoc-4-Fluorobenzylglycine; N-α-Fmoc-N-ω-(4-fluorobenzyl)glycine; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-[(4-fluorophenyl)methyl]-
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-Fluorobenzyl-Glycine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.