Description

1-Methyl-3-Trifluoromethylpyrazole-5-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with pyrazole cores, particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require trifluoromethylpyrazole motifs.
• Material Science Research: Employed in the creation of advanced organic electronic materials, such as OLED emitters and charge transport layers.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized bidentate ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Facilitates the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	1-Methyl-3-Trifluoromethylpyrazole-5-Boronic Acid Pinacol Ester
CAS No.	1025719-23-6
Molecular Formula	C11H16BF3N2O2
Molecular Weight	276.07 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole; 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-boronic acid pinacol ester; (1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)boronic acid pinacol ester; 3-Trifluoromethyl-1-methyl-1H-pyrazole-5-boronic acid pinacol ester; 5-Borono-1-methyl-3-trifluoromethylpyrazole pinacol ester; Pyrazole boronic ester, 1-methyl-3-trifluoromethyl-; B-[1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-Trifluoromethylpyrazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency for reliable cross-coupling performance. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, the container should be allowed to reach room temperature before opening to minimize moisture ingress and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.