Description

2,5-Difluoro-6-Methylbenzeneboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures in modern organic synthesis. It is an essential building block for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, facilitating the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethyl-substituted aromatic or heteroaromatic cores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic motifs for enhanced activity and stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for OLEDs and semiconductors, where fluorination tunes electronic properties.
• Chemical Biology & Probe Development: Serves as a precursor for fluorinated chemical probes and tags used in bioimaging and target identification studies.
• Catalyst & Ligand Preparation: Utilized in the synthesis of sophisticated, fluorinated ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	2,5-Difluoro-6-Methylbenzeneboronic Acid, Pinacol Ester
CAS No.	1025707-98-5
Molecular Formula	C13H17BF2O2
Molecular Weight	254.08 g/mol
Synonyms	2,5-Difluoro-6-methylbenzeneboronic acid pinacol ester; (2,5-Difluoro-6-methylphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2,5-difluoro-6-methylphenyl)-1,3,2-dioxaborolane; 2-(2,5-Difluoro-6-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-(2,5-difluoro-6-methylphenyl)-, 1,1-dimethylethyl ester; 2,5-Difluoro-6-methylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 2,5-Difluoro-6-Methylbenzeneboronic Acid, Pinacol Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Quality is verified via advanced analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.