Description

3,4-Difluoro-2-Methylphenyl Boronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is essential for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures in modern organic synthesis. It is a critical building block for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, enabling the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethylphenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the difluoro and methyl substitutions can fine-tune biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or building block for constructing organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Chemical Library Production: Utilized in parallel and combinatorial synthesis for high-throughput screening to discover new bioactive compounds.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in synthetic organic chemistry and for preparing complex molecular targets.

Basic Information

Product Name	3,4-Difluoro-2-Methylphenyl Boronic Acid Pinacol Ester
CAS No.	1025707-97-4
Molecular Formula	C13H17BF2O2
Molecular Weight	254.09 g/mol
Synonyms	2-Methyl-3,4-difluorophenylboronic acid pinacol ester; (3,4-Difluoro-2-methylphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(3,4-difluoro-2-methylphenyl)-1,3,2-dioxaborolane; Pinacol (3,4-difluoro-2-methylphenyl)boronate; Boronic acid, B-(3,4-difluoro-2-methylphenyl)-, 1,1-dimethylethyl ester (9CI); 3,4-Difluoro-2-methylbenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity (HPLC/GC), identity (NMR, IR), and impurity profiles are available upon request. We adhere to a quality management system to support our commitment to reliable supply for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.