Description

3-Butenoic Acid, 2-[[(9 H -Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (2S)- is a high-purity, non-natural amino acid derivative featuring a versatile terminal alkene handle. This compound is a critical Fmoc-protected building block designed for advanced solid-phase peptide synthesis (SPPS) and bioconjugation strategies. It is essential for researchers and manufacturers in pharmaceutical development and biotechnology who require precise, site-specific modifications to create novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the controlled assembly of custom peptide sequences, enabling the incorporation of a reactive alkene group at a defined position.
• Bioconjugation & Click Chemistry: The terminal alkene functionality allows for site-specific modification via thiol-ene reactions or other alkene-based chemistries, facilitating the labeling or functionalization of peptides, proteins, and other biomolecules.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide drugs, including constrained peptides, peptide-drug conjugates (PDCs), and targeted therapeutics.
• Chemical Biology Probes: Enables the synthesis of activity-based probes and affinity tags for studying protein function, interactions, and localization within biological systems.
• Material Science: Incorporation into peptide-based polymers or hydrogels to introduce cross-linking points or reactive sites for further material functionalization.

Basic Information

Item	Details
Product Name	3-Butenoic Acid, 2-[[(9 H -Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (2S)-
CAS No.	1025434-04-1
Molecular Formula	C19H17NO4
Molecular Weight	323.34 g/mol
Synonyms	Fmoc-L-2-Amino-4-pentenoic acid; Fmoc-L-homoallylglycine-OH; Fmoc-Hag-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid; N-α-Fmoc-L-2,4-diaminobut-4-enoic acid; Fmoc-L-DABA(Alloc); N-Fmoc-L-homoallylglycine
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) with full analytical data are provided for traceability and to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.