Description

Olaratumab CAS NO 1024603-93-7 is a fully human monoclonal antibody specifically designed to target and inhibit the platelet-derived growth factor receptor alpha (PDGFR-α). This targeted mechanism is critical for disrupting tumor growth and metastasis pathways in certain cancers. It is primarily utilized in advanced pharmaceutical research and development for oncology applications. Our supply ensures high purity and batch-to-batch consistency essential for preclinical and clinical studies.

Application

• Oncological Research: Investigation of PDGFR-α signaling pathways in various solid tumors.
• Drug Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of targeted cancer therapies.
• Biomarker Studies: Used in assays to study receptor expression and inhibition efficacy.
• Preclinical Modeling: Essential for in vitro and in vivo studies to evaluate anti-tumor activity and combination therapies.
• Clinical Trial Materials: Sourced for use in regulated clinical research phases.
• Diagnostic Development: Potential use in companion diagnostic tests to identify patient populations likely to respond to PDGFR-α targeted treatment.

Basic Information

Product Name	Olaratumab
CAS No.	1024603-93-7
Molecular Formula	C6448H9916N1704O2018S46
Molecular Weight	Approx. 145 kDa
Synonyms	IMC-3G3; Anti-PDGFR-α Monoclonal Antibody; LY3012207; Olaratumab (INN); Monoclonal Antibody IMC-3G3; PDGFR Alpha Antibody, IMC-3G3; Recombinant Human Anti-PDGFR Alpha IgG1 Antibody
EINECS	Contact for details

Quality Control

Our Olaratumab is manufactured under strict quality systems. Each batch is rigorously tested to ensure identity, purity, potency, and safety, meeting high standards for research and development use. Certificates of Analysis (COA) are provided, detailing comprehensive analytical results from methods including HPLC, SDS-PAGE, and bioactivity assays. We adhere to relevant portions of cGMP guidelines for API production to ensure reliable and consistent material for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled, dry conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE, reduced & non-reduced)	> 95%
Purity (SEC-HPLC)	> 98% Monomer
Assay (HPLC)	90.0% - 110.0% of label claim
Protein Content (A280)	Conforms to label claim
Endotoxin	< 1.0 EU/mg
Bioactivity (Cell-based assay)	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.